Prof. Dr. Hilmar BadingPublications

Marty-Lombardi, S., Lu, S., Ambroziak, W., Schrenk-Siemens, K., Wang, J., DePaoli-Roach, A. A., Hagenston, A. M., Wende, H., Tappe-Theodor, A., Simonetti, M., Bading, H., Okun, J. G., Kuner, R., Fleming, T., & Siemens, J. (2024). Neuron-astrocyte metabolic coupling facilitates spinal plasticity and maintenance of inflammatory pain. Nature metabolism, 10.1038/s42255-024-01001-2. Advance online publication. https://doi.org/10.1038/s42255-024-01001-2

Yan, J., Wang, Y. M., Hellwig, A., & Bading, H. (2024). TwinF interface inhibitor FP802 stops loss of motor neurons and mitigates disease progression in a mouse model of ALS. Cell reports. Medicine, 5(2), 101413. https://doi.org/10.1016/j.xcrm.2024.101413

Nassrallah, W. B., Ramandi, D., Cheng, J., Oh, J., Mackay, J., Sepers, M. D., Lau, D., Bading, H., & Raymond, L. A. (2023). Activin A targets extrasynaptic NMDA receptors to ameliorate neuronal and behavioral deficits in a mouse model of Huntington disease. Neurobiology of disease, 189, 106360. https://doi.org/10.1016/j.nbd.2023.106360

Pruunsild, P., Bengtson, C. P., Loss, I., Lohrer, B., & Bading, H. (2023). Expression of the primate-specific LINC00473 RNA in mouse neurons promotes excitability and CREB-regulated transcription. The Journal of biological chemistry, 299(5), 104671. https://doi.org/10.1016/j.jbc.2023.104671

Gleitze, S., Ramírez, O. A., Vega-Vásquez, I., Yan, J., Lobos, P., Bading, H., Núñez, M. T., Paula-Lima, A., & Hidalgo, C. (2023). Ryanodine Receptor Mediated Calcium Release Contributes to Ferroptosis Induced in Primary Hippocampal Neurons by GPX4 Inhibition. Antioxidants (Basel, Switzerland), 12(3), 705. https://doi.org/10.3390/antiox12030705

Fröhlich, A., Olde Heuvel, F., Rehman, R., Krishnamurthy, S. S., Li, S., Li, Z., Bayer, D., Conquest, A., Hagenston, A. M., Ludolph, A., Huber-Lang, M., Boeckers, T., Knöll, B., Morganti-Kossmann, M. C., Bading, H., & Roselli, F. (2022). Neuronal nuclear calcium signaling suppression of microglial reactivity is mediated by osteoprotegerin after traumatic brain injury. Journal of neuroinflammation, 19(1), 279. https://doi.org/10.1186/s12974-022-02634-4

Oberländer, K., Witte, V., Mallien, A. S., Gass, P., Bengtson, C. P., & Bading, H. (2022). Dysregulation of Npas4 and Inhba expression and an altered excitation-inhibition balance are associated with cognitive deficits in DBA/2 mice. Learning & memory (Cold Spring Harbor, N.Y.), 29(2), 55–70. https://doi.org/10.1101/lm.053527.121

Bauersachs, H. G., Bengtson, C. P., Weiss, U., Hellwig, A., García-Vilela, C., Zaremba, B., Kaessmann, H., Pruunsild, P., & Bading, H. (2022). N-methyl-d-aspartate Receptor-mediated Preconditioning Mitigates Excitotoxicity in Human Induced Pluripotent Stem Cell-derived Brain Organoids. Neuroscience, 484, 83–97.https://doi.org/10.1016/j.neuroscience.2021.12.026

Hagenston, A. M., Yan, J., Bas-Orth, C., Tan, Y., Sekler, I., & Bading, H. (2022). Disrupted expression of mitochondrial NCLX sensitizes neuroglial networks to excitotoxic stimuli and renders synaptic activity toxic. The Journal of biological chemistry, 298(2), 101508. https://doi.org/10.1016/j.jbc.2021.101508

Fairless, R., Bading, H., & Diem, R. (2021). Pathophysiological Ionotropic Glutamate Signalling in Neuroinflammatory Disease as a Therapeutic Target. Frontiers in neuroscience, 15, 741280. https://doi.org/10.3389/fnins.2021.741280

Lissek, T., Andrianarivelo, A., Saint-Jour, E., Allichon, M. C., Bauersachs, H. G., Nassar, M., Piette, C., Pruunsild, P., Tan, Y. W., Forget, B., Heck, N., Caboche, J., Venance, L., Vanhoutte, P., & Bading, H. (2021). Npas4 regulates medium spiny neuron physiology and gates cocaine-induced hyperlocomotion. EMBO reports, 22(12), e51882. https://doi.org/10.15252/embr.202051882

Mozolewski, P., Jeziorek, M., Schuster, C. M., Bading, H., Frost, B., & Dobrowolski, R. (2021). The role of nuclear Ca2+ in maintaining neuronal homeostasis and brain health. Journal of cell science, 134(8), jcs254904. https://doi.org/10.1242/jcs.254904

Yan, J., Bengtson, C. P., Buchthal, B., Hagenston, A. M., & Bading, H. (2020). Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants. Science (New York, N.Y.), 370(6513), eaay3302.  https://doi.org/10.1126/science.aay3302

Merz, S. F., Bengtson, C. P., Tepohl, C., Hagenston, A. M., Bading, H., & Bas-Orth, C. (2020). A microscopy-based small molecule screen in primary neurons reveals neuroprotective properties of the FDA-approved anti-viral drug Elvitegravir. Molecular brain, 13(1), 124. https://doi.org/10.1186/s13041-020-00641-1

Maurer, J., Yanez, A., Bengtson, C. P., Bading, H., Draguhn, A., Mauceri, D., & Both, M. (2020). VEGF-D Downregulation in CA1 Pyramidal Neurons Exerts Asymmetric Changes of Dendritic Morphology without Correlated Electrophysiological Alterations. Neuroscience, 448, 28–42. https://doi.org/10.1016/j.neuroscience.2020.09.012

Mauceri, D., Buchthal, B., Hemstedt, T. J., Weiss, U., Klein, C. D., & Bading, H. (2020). Nasally delivered VEGFD mimetics mitigate stroke-induced dendrite loss and brain damage. Proceedings of the National Academy of Sciences of the United States of America, 117(15), 8616–8623. https://doi.org/10.1073/pnas.2001563117

Bas-Orth, C., Koch, M., Lau, D., Buchthal, B., & Bading, H. (2020). A microRNA signature of toxic extrasynaptic N-methyl-D-aspartate (NMDA) receptor signaling. Molecular brain, 13(1), 3. https://doi.org/10.1186/s13041-020-0546-0

Moldavski, A., Behr, J., Bading, H., & Bengtson, C. P. (2020). A novel method using ambient glutamate for the electrophysiological quantification of extrasynaptic NMDA receptor function in acute brain slices. The Journal of physiology, 598(4), 633–650. https://doi.org/10.1113/JP278362

Bas-Orth, C., Schneider, J., Lewen, A., McQueen, J., Hasenpusch-Theil, K., Theil, T., Hardingham, G. E., Bading, H., & Kann, O. (2020). The mitochondrial calcium uniporter is crucial for the generation of fast cortical network rhythms. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 40(11), 2225-2239. https://doi.org/10.1177/0271678X19887777

Hagenston, A. M., Bading, H., & Bas-Orth, C. (2020). Functional Consequences of Calcium-Dependent Synapse-to-Nucleus Communication: Focus on Transcription-Dependent Metabolic Plasticity. Cold Spring Harbor perspectives in biology, 12(4), a035287. https://doi.org/10.1101/cshperspect.a035287